Bien que pas un nom de code ou pseudonyme formelle, il a été une fois appelé «Fils de The Boss" par le colonel Volgin juste avant leur combat dans le hangar de Groznyj Grad, en référence au fait qu'il était dernier disciple de The Boss. Big Boss a exprimé de fortes réticences à l'égard des exigences parfois bancales et déraisonnables de Zéro pour le contrôle (c.-à-d. soif de pouvoir). After an inconclusive fist fight, Ocelot instead suggested that he and Snake should settle it in a game that combined Russian roulette and quick draw, but not before they exchanged their real first names with each other (Adamska and John). Big Boss revealed his presence to the startled Snake, disarming him with CQC after the latter drew his weapon in surprise.
Naked Snake appeared as a unique character in the Online Mode of His trophy depiction had him wearing bandages over his torso and arms, referring to the injuries he sustained both when fighting against The Boss in the ending of the Virtuous Mission, and when he was tortured by Colonel Volgin during Operation Snake Eater.
When Snake refused to break, The Boss stepped and tried to convince Volgin that his attempts were in vain as she had personally trained Snake to never give in to torture, but a frustrated Volgin instead intensified the torture while asking Snake if he was after the Philosophers' Legacy he had in his possession, before telling him that he had hidden the Legacy in an underground vault in Groznyj Grad, so he would never get his hands on it. Liquid planned to use Big Boss's DNA to cure genetic mutations in the Genome Soldiers, and to recreate Big Boss's dream of Outer Heaven, utilizing the threat of a nuclear strike with the stolen Prior to 2014, Big Boss's DNA and biometric data was used for the Patriots' ID recognition system, the use of which allowed access to their AI network. A sa mort en 2014, Big Boss a finalement réalisé ce que sa volonté était finale. Big Boss met Sigint during Operation Snake Eater, who was assigned to give him intel on weapons, camouflage, armor, and vehicles. When he arrived at The Boss's grave, he reflected back on the day he killed The Boss, sorrowfully admitting that he was "already dead" ever since.
However, as a result of Volgin's unanticipated decision to detonate one of the American nuclear warheads in a display that would destroy Sokolov's research facility, the U.S. was forced to go with a change in plans, having decided that sacrificing The Boss' life at the hands of Snake, her own favorite trainee and disciple, would be the best way of outwardly proving America's innocence to the Soviets. Cependant, Huey, le seul membre de MSF qui a soutenu l'inspection, a fini par envoyer une autre lettre qui indique qu'ils ont changé d'avis, forçant Big Boss pour permettre l'inspection de se produire, car il aurait autrement absorbé trop de soupçons. L'un d'eux était un jeune Sniper Wolf, qu'il a sauvé d'une éducation sévère et a grandi en tant que soldat. Cependant, les batailles, les soldats seraient confrontés ceux qui ont été choisis pour, indépendamment de qui a donné l'ordre, et qu'ils ne sauraient pas de vie, mais le combat. During the torture, a Back in his holding cell, Snake managed to outwit the prison guard, Snake fought his mentor with great reluctance, and after a fierce battle, he eventually incapacitated her. Il a également détourné une ambulance et mis Venom Snake en sécurité, mais il a disparu après l'accident de voiture quand Ocelot est arrivé. Volgin then turned his attention to Snake, repeatedly hitting him and electrocuting him with his lightning powers, while demanding to know the details of his mission and if he had any accomplices.